Table 1:
Baseline Characteristics of Individual Patients Newly Diagnosed with Cardiac Amyloidosis (Incidence Cohort), 2000–2012
| 2000 | 2012 | P value (linear trend from 2000 to 2012) | Aggregated (2000–2012) | |
|---|---|---|---|---|
| New Cases of Cardiac Amyloidosis (incidence) | 2101 | 4746 | 38254 | |
| Demographics | ||||
| Age group, (%) | <0.001 | |||
| 65–74 | 853 (40.6) |
1638 (34.5) |
13832 (36.2) |
|
| 75–84 | 927 (44.1) |
1930 (40.7) |
16367 (42.8) |
|
| 85+ | 321 (15.3) |
1178 (24.8) |
8055 (21.1) |
|
| Gender, (%) | 0.177 | |||
| Female | 1079 (51.4) |
2454 (51.7) |
19270 (50.4) |
|
| Race, (%) | <0.001 | |||
| White | 1757 (83.6) |
3763 (79.3) |
31015 (81.1) |
|
| Black | 259 (12.3) |
728 (15.3) |
5451 (14.3) |
|
| Other | 85 (4.0) |
255 (5.4) |
1788 (4.7) |
|
| Gender and Race, (%) | <0.001 | |||
| White Men | 867 (41.3) |
1843 (38.8) |
15687 (41.0) |
|
| White Women | 890 (42.4) |
1920 (40.5) |
15328 (40.1) |
|
| Black Men | 118 (5.6) |
331 (7.0) |
2470 (6.5) |
|
| Black Women | 141 (6.7) |
397 (8.4) |
2981 (7.8) |
|
| Other Men | 37 (1.8) |
118 (2.5) |
827 (2.2) |
|
| Other Women | 48 (2.3) |
137 (2.9) |
961 (2.5) |
|
| Dual-Eligible Enrollment, (%) | 270 (12.9) |
685 (14.4) |
<0.001 | 5186 (13.6) |
| Geography, (%) | <0.001 | |||
| Midwest | 790 (37.6) |
1760 (36.0) |
13912 (36.4) |
|
| Northeast | 475 (22.6) |
1286 (27.1) |
9750 (25.5) |
|
| South | 541 (25.8) |
973 (20.5) |
8391 (21.9) |
|
| West | 295 (14.0) |
781 (16.5) |
6198 (16.2) |
|
| Prior Heart Failure Hospitalizations*, (%) | ||||
| Heart Failure Hospitalization in prior 30-days of the index amyloidosis-related admission (%) | 42 (2.0) |
91 (1.9) |
0.505 | 833 (2.2%) |
| Heart Failure Hospitalization in prior 1-year of the index amyloidosis-related admission (%) | 180 (8.6) |
356 (7.5%) |
0.001 | 3087 (8.1) |
| Past Medical History, f(%) | ||||
| Acute Myocardial Infarction | 26 (1.2) |
126 (2.7) |
0.012 | 883 (2.3) |
| Unstable Angina | 32 (1.5) |
61 (1.3) |
0.328 | 517 (1.4) |
| Cardiac Atherosclerosis | 432 (20.6) |
1055 (22.2) |
0.059 | 8862 (23.2) |
| Hypertension | 894 (42.6) |
2984 (62.9) |
<0.001 | 21288 (55.4) |
| Atrial Fibrillation | 391 (18.6) |
985 (20.8) |
0.025 | 7588 (19.8) |
| Stroke | 142 (6.8) |
393 (8.3) |
0.003 | 2900 (7.6) |
| Renal Failure | 174 (8.3) |
772 (16.3) |
<0.001 | 5314 (13.9) |
| Chronic Obstructive Pulmonary Disease | 338 (16.1) |
539 (11.4) |
<0.001 | 5206 (13.6) |
| Pneumonia | 194 (9.2) |
554 (11.7) |
<0.001 | 4269 (11.2) |
| Dementia | 262 (12.5) |
801 (16.9) |
<0.001 | 6892 (18.0) |
| Diabetes | 289 (13.8) |
933 (19.7) |
<0.001 | 6503 (17.0) |
| Anemia | 532 (25.3) |
1166 (24.6) |
<0.001 | 9337 (24.4) |
| Autonomic Neuropathy | 132 (6.3) |
205 (4.32) |
<0.001 | 1943 (5.1) |
| Carpel Tunnel Syndrome | 16 (0.8) |
16 (0.3) |
0.013 | 137 (0.4) |
| Orthostatic Hypotension | 191 (9.1) |
630 (13.3) |
<0.001 | 4617 (12.07) |
| Multiple Myeloma | 238 (11.3) |
343 (7.2) |
<0.001 | 3553 (9.3) |
| Nephrotic Syndrome | 36 (1.7) |
65 (1.4) |
<0.001 | 574 (1.5) |
| Pleural Effusion | 103 (4.9) |
268 (0.7) |
<0.001 | 2248 (5.9) |
Biceps tendon rupture, macroglossia, periorbital bruising and peripheral neuropathy were excluded due to counts <11
*
Prior Heart Failure Hospitalization includes any prior hospitalizations within the designated time period with a primary diagnosis of heart failure. No secondary diagnoses are considered.