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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Mol Genet Metab. 2018 Jun 15;125(1-2):118–126. doi: 10.1016/j.ymgme.2018.06.006

Figure 6.

Figure 6.

Folate metabolism pathway. Folate metabolites are in bold. Enzymes are in italics. The dashed line represents inhibition of the enzyme serine hydroxymethyltransferase by 5-formyl THF polyglutamate. THF = tetrahydrofolate, DHF = dihydrofolate, MTHFS = 5,10-methenyltetrahydrofolate synthetase, FGAR = formylglycinamide ribotide, GAR=glycinamide ribotide, AICAR = aminoimidazole carboxamide ribotide, FAICAR = formylaminoimidazole carboxamide ribotide, dTMP = deoxythmidine monophosphate, dUMP = deoxyuridine monophosphate.