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. Author manuscript; available in PMC: 2020 May 17.
Published in final edited form as: J Mol Biol. 2019 Apr 26;431(11):2068–2081. doi: 10.1016/j.jmb.2019.04.028

Figure 6. Protein partners of nuclear human DNA ligases.

Figure 6.

(a) The N-terminal domain of DNA ligase I, including the first 232 amino acid residues of the protein, interacts with the N-terminal part of DNA polymerase β harboring an 8 kDa lyase domain that is responsible for 5′-dRP removal. The PIP box of DNA ligase I mediates its interaction with proliferating cell nuclear antigen (PCNA). (b) The ovarian cancer susceptibility protein 1 (BRCT) and zincbinding (ZnF) domains of DNA ligase IIIα mediates protein-protein interactions with X-ray repair cross-complementing protein 1 (XRCC1) and Poly(ADP-Ribose) Polymerase 1 (PARP1), respectively. (c) DNA ligase IV forms a functional complex with X-ray repair crosscomplementing protein 4 (XRCC4) through its two BRCA1 C-terminal (BRCT) domains.