Table 1. Patient characteristics and univariate comparison between treatment groups.

Parameter	Overall value (n = 100)	Bepanthen (n = 66)	R1&R2 (n = 34)	p-value*
Median age, years (range)	62.1 (36.5–80.8)	62.1 (36.5–80.5)	62.2 (39.8–80.9)	0.51
Skin Type, Fitzpatrick scale				0.92
2	32	22 (33.3%)	10 (29.4%)
3	60	39 (59.1%)	21 (61.8%)
4	8	5 (7.6%)	3 (8.8%)
Mean CIELAB (±SD) of untreated skin
L*	66.66 (±6.99)	66.74 (±6.43)	66.5 (±8.05)	0.87
a*	6.91 (±3.16)	6.57 (±3.12)	7.56 (±3.16)	0.13
b*	16.53 (±4.75)	16.22 (±4.62)	17.11 (±5.01)	0.37
Tumor stage				0.75
1	68	46 (69.7%)	22 (64.7%)
2	28	17 (25.8%)	11 (32.4%)
3	4	3 (4.5%)	1 (2.9%)
Prior chemotherapy				0.69
yes	27	17 (25.8%)	10 (29.4%)
no	73	49 (74.2%)	24 (70.6%)
Endocrine therapy				0.67
yes	80	52 (78.8%)	28 (82.3%)
no	20	14(21.2%)	6 (17.7%)
Breast cup size				0.06
A	11	7 (10.6%)	4 (11.8%)
B	42	34 (51.5%)	8 (23.5%)
C	30	17 (25.8%)	13 (38.2%)
D	13	7 (10.6%)	6 (17.7%)
E	4	1 (1.5%)	3 (8.8%)

CIELAB, color space by the French Commission Internationale de l'Éclairage; L*, represents the lightness; a*, the green–red color components; b*, the blue–yellow components; SD, standard deviation.

* p-values were calculated using t-test or chi-square test.