Table 6. Associations between co-amoxiclav resistance among E. coli urinary samples and antibiotic prescribing (DDD per 1000 persons per day).

Antibiotic prescribed	Co-amoxiclav resistance, antibiotic prescribing 1 month before. RR (2.5th–97.5th percentile of bootstrap)	Co-amoxiclav resistance, antibiotic prescribing 1–3 month before. RR (2.5th–97.5th percentile of bootstrap)	Co-amoxiclav resistance, antibiotic prescribing 1 year before. RR (2.5th–97.5th percentile of bootstrap)
Tetracyclines (J01AA)	1.03 (0.89–1.31)	1.04 (0.87–1.33)	1.04 (0.87–1.35)
Penicillins with extended spectrum (J01CA)	0.99 (0.74–1.00)	0.98 (0.70–1.00)	0.97 (0.68–1.02)
Beta-lactamase-sensitive penicillins (J01CE)	-	-	1.00 (1.00–8.86)
Combinations of penicillins, including β-lactamase inhibitors (J01CR)	-	-	1.00 (0.51–2.62)
Trimethoprim and derivatives (J01EA)	-	-	1.00 (0.54–2.30)

^a Associations for which 2.5^th and 97.5^th percentile of the clustered bootstrap are both indicating an increased or decreased risk. Results are adjusted for differences in the test rate, time and use of other antibiotics (full model results shown in table E in S2 File).