Table 1. Indices showing the inhibitory activity of diaphorin against the 39 human cancer cell lines.
| Cell line | GI50 (μM) | TGI (μM) | LC50 (μM) |
|---|---|---|---|
| Breast cancer | |||
| BSY-1 | 0.40 | 1.9 | 8.4 |
| HBC-4 | 0.28 | 1.6 | 13 |
| HBC-5 | 0.35 | 1.7 | 16 |
| MCF-7 | 0.46 | 3.3 | 40 |
| MDA-MB-231 | 0.71 | 3.2 | 19 |
| CNS cancer | |||
| SF-268 | 0.46 | 6.0 | >100 |
| SF-295 | 0.38 | 2.9 | 46 |
| SF-539 | 0.56 | 2.3 | 7.5 |
| SNB-75 | 0.45 | 2.7 | 52 |
| SNB-78 | 0.51 | 3.0 | 61 |
| U251 | 0.34 | 4.2 | >100 |
| Colon cancer | |||
| HCC2998 | 0.74 | 3.8 | 31 |
| HCT-116 | 1.0 | 6.3 | 40 |
| HCT-15 | 2.4 | 11 | >100 |
| HT-29 | 1.3 | 7.1 | 54 |
| KM-12 | 0.54 | 4.7 | >100 |
| Lung cancer | |||
| A549 | 0.47 | 7.0 | >100 |
| DMS114 | 1.1 | 4.8 | 65 |
| DMS273 | 1.3 | 5.0 | 35 |
| NCI-H226 | 0.34 | 1.8 | 55 |
| NCI-H23 | 1.3 | 8.1 | >100 |
| NCI-H460 | 1.2 | 8.3 | 55 |
| NCI-H522 | 0.37 | 2.3 | 43 |
| Melanoma | |||
| LOX-IMVI | 1.3 | 3.9 | 17 |
| Ovarian cancer | |||
| OVCAR-3 | 1.3 | 5.8 | >100 |
| OVCAR-4 | 0.35 | 1.6 | 16 |
| OVCAR-5 | 0.56 | 3.8 | 43 |
| OVCAR-8 | 0.93 | 4.7 | 67 |
| SK-OV-3 | 0.34 | 2.1 | 34 |
| Renal cancer | |||
| ACHN | 1.4 | 6.6 | >100 |
| RXF-631L | 1.5 | 4.5 | 34 |
| Stomach cancer | |||
| MKN-A | 1.6 | 6.4 | 45 |
| MKN-B | 2.0 | 6.8 | 43 |
| MKN1 | 0.78 | 4.4 | 32 |
| MKN45 | 0.37 | 2.9 | 84 |
| MKN74 | 0.93 | 5.3 | 67 |
| St-4 | 1.0 | 5.8 | >100 |
| Prostate cancer | |||
| DU-145 | 1.3 | 5.1 | >100 |
| PC-3 | 0.96 | 7.1 | >100 |