Skip to main content
. 2019 May 29;17(5):e3000287. doi: 10.1371/journal.pbio.3000287

Fig 3. The intermediate cellular population expresses high levels of chemokines and their receptors.

Fig 3

A) Heat map showing elevated expression of inflammatory chemokines and their receptors in the intermediate population compared to the monocyte population. B) CXCL4 is much more strongly expressed in intermediate population than in the monocyte population. C) i) Flow cytometric analysis demonstrating separate populations of CXCL4– and CXCL4hi cells within the overall CD11bhi gate (left-hand panel) and showing the CXCL4hi cells to be predominantly F4/80mid (right-hand panel; blue line, CXCL4– and red line, CXCL4hi). ii) Flow cytometric analysis demonstrating GP49 expression by CXCL4– and CXCL4hi myelomonocytic cells. Data associated with this figure can be found in the supplemental data file (S2 Data). ACKR, atypical chemokine receptor; CCL, CC ligand; CCR, CC chemokine receptor; CXCL, CXC ligand; CXCR, CXC chemokine receptor; GP49, glycoprotein 49; Pf4, platelet factor 4.