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a: Apical iron uptake after the first (0-15 min) and second (15-30 min) iron challenges. (∘): experimental data; (–): model simulation. b: Simulation of DMT1 endocytic cycling behavior during iron absorption for the first (0-15 min) and second (15-30 min) iron challenges. (orange line): Fraction of DMT1 in the apical membrane (P1 + P2 + P3 + P4); (blue line): Fraction of DMT1 in the endocyted state (P5 + P6).
