Table 2.

Top 20 genes with differentially methylated CpGs in offspring cord blood associated with maternal obesity before and after adjustment for cell proportions, among females (n = 187).

Unadjusted for cell proportion					Adjusted for cell proportion
Annotated Genea	# of CpG sites	Chr.	Median Methylation Differenceb	P-valuec (min, max)	Annotated Genea	# of CpG sites	Chr.	Median Methylation Differenceb	P-valuec (min, max)
TAPBP	30	chr6	0.76%	3.39e−26, 2.65e−02	TAPBP	57	chr6	0.91%	1.09e−12, 4.24e−02
HMHB1	7	chr5	2.83%	7.40e−10, 2.26e−03	RP11-109A6.3	13	chr10	−0.90%	1.04e−17, 1.18e−02
WT1	25	chr11	−1.93%	1.57e−07, 2.64e−02	NFE2L3	6	chr7	4.40%	2.00e−07, 3.69e−05
PSMB9	11	chr6	−1.41%	1.73e−06, 1.80e−02	GLIPR1L2	11	chr12	2.96%	3.30e−07, 3.48e−06
DDR1	30	chr6	−1.48%	2.31e−06, 4.33e−02	MFSD1	10	chr3	−1.12%	2.26e−06, 3.00e−02
PCDHGA4	38	chr5	−1.52%	4.01e−06, 4.97e−02	HOXC4	22	chr12	−1.78%	5.71e−06, 4.30e−02
PPT2	42	chr6	−0.97%	4.02e−06, 4.41e−02	LSP1	14	chr11	0.56%	8.30e−06, 1.89e−02
GLIPR1L2	11	chr12	3.20%	4.10e−06, 7.31e−06	WT1	16	chr11	−1.89%	2.01e−05, 3.60e−02
BRCA1	26	chr17	0.94%	4.72e−06, 3.80e−02	DDR1-006	14	chr6	−1.70%	4.49e−05, 4.52e−02
FLJ12825	8	chr12	−1.80%	5.37e−06, 2.01e−02	CKMT2	9	chr5	−1.54%	5.23e−05, 3.70e−02
FBXO27	9	chr19	−2.3%	6.22e−06, 1.44e−02	MEST	15	chr7	1.33%	7.55e−05, 4.51e−02
LYPD3	8	chr19	−1.57%	6.68e−06, 1.13e−02	APOB	12	chr2	−2.09%	7.97e−05, 2.08e−03
TMEM187	12	chrX:	−1.65%	9.09e−06, 4.66e−03	LINC00336	9	chr6	2.25%	9.39e−05, 1.12e−03
CSNK1E	11	chr22	−1.82%	9.17e−06, 3.17e−02	C17orf64	9	chr17	−2.06%	1.50e−04, 1.25e−03
GRB7	13	chr17	−1.10%	1.04e−05, 2.06e−02	PCDHB15	4	chr5	−2.41%	3.47e−04, 3.11e−03
BAT1	29	chr6	1.13%	1.06e−05, 1.70e−02	PRR5L	5	chr11	3.64%	4.97e−04, 6.38e−04
EIF2C2	5	chr8	1.78%	1.07e−05, 1.33e−05	HOXB5	3	chr17	1.51	6.07e−04, 1.18e−02
MFSD1	10	chr3	−1.05%	1.13e−05, 3.64e−02	SEPT8-003	10	chr5	−1.63%	6.64e−04, 2.36e−02
GPSM3	10	chr6	1.68%	1.39e−05, 2.60e−02	STK10	4	chr5	−1.45%	6.75e−04, 1.17e−03
ATF7	1	chr12	7.16%	1.69e−05	PCDHGB8P-002	7	chr5	−2.88%	4.20e−04, 2.48e−02

^aAnnotated genes shown according to FDR-corrected p-value in ascending order

^bMedian Methylation difference across all significant CpG sites annotated to denoted gene

^cMinimum and maximum p-value for significant CpG sites annotated to denoted gene