Table 4.
Associationsa of TAPBP DNA methylation sitesb with child BMI z-score and elevated blood pressure at 4–5 years of age, among 238 female and male offspring in NEST cohort.
| Females |
Males |
|||||
|---|---|---|---|---|---|---|
| TAPBP genec, d | BMI z-score β (95% CI) |
Systolic Blood Pressure Percentile β (95% CI) |
Diastolic Blood Pressure Percentile β (95% CI) |
BMI z-score β (95% CI) |
Systolic Blood Pressure Percentile β (95% CI) |
Diastolic Blood Pressure Percentile β (95% CI) |
| cg23922433 | 1.58 (0.73, 0.14) | 4.23 (−22.46, 30.92) | 10.51 (13.64, 34.66) | – | – | – |
| cg16632096 | 0.28 (−1.08, 1.63) | −10.24 (−35.84, 15.37) | −11.44 (−34.65, 11.77) | – | – | – |
| cg17621507 | −1.18 (−2.22, −0.16) | −2.77 (−25.12, 19.59) | 2.67 (−17.64, 22.97) | – | – | – |
| cg03780271 | 0.21 (−1.22, 1.63) | 2.64 (−22.29, 27.56) | 4.29 (−18.34, 26.91) | −0.32 (−1.19, 0.55) | −5.78 (−30.15, 15.59) | −23.70 (−41.17, −6.23) |
| cg12589538 | −0.09 (−1.21, 1.03) | 0.70 (−20.09, 21.50) | 5.63 (−13.22, 24.48) | 0.04 (−0.81, 0.89) | 3.55 (−20.11, 27.22) | −8.59 (−26.19, 9.00) |
| cg11796996 | −0.08 (−2.51, 0.87) | −2.10 (−33.46, 29.25) | 3.65 (−.24.82, 32.12) | −0.59 (−1.69, 0.51) | 11.01 (−20.65, 42.68) | −14.60 (−38.11, 8.92) |
| cg02863594 | 0.59 (−0.95, 2.12) | −23.56 (−50.58, 3.46) | 6.15 (−18.82, 31.11) | −0.58 (−1.71, 0.56) | 22.31 (−8.27, 52.90) | −5.05 (−28.18, 18.08) |
| cg01253676 | −0.03 (−1.38, 1.31) | −9.21 (−33.86, 15.43) | 0.51 (−23.95, 22.97) | −0.21 (−1.22, 0.80) | 9.22 (−18.95, 37.40) | 0.41 (−20.70, 21.53) |
| cg20998791 | 0.25 (−0.84, 1.35) | −10.25 (−29.39, 8.89) | −1.06 (−18.56, 16.45) | −0.13 (−1.02, 0.77) | 9.41 (−14.18, 33.00) | −4.68 (−22.25, 12.99) |
| cg18353226 | 0.28 (−0.80, 1.35) | −6.19 (−25.22, 12.84) | −0.92 (−18.25, 16.41) | 0.12 (−0.68, 0.92) | 7.84 (−14.20, 29.88) | −3.01 (−19.52, 13.50) |
| cg14419102 | 0.32 (−0.57, 1.22) | −12.56 (−28.44, 3.31) | −0.07 (−14.58, 14.71) | 0.28 (−0.39, 0.95) | 5.60 (−12.82, 24.01) | −3.38 (−17.16, 10.39) |
| cg06375761 | 0.26 (−0.46, 0.97) | −9.30 (−22.28, 3.68) | −2.58 (−14.51, 9.34) | 0.12 (−0.41, 0.64) | 7.60 (−6.55, 21.75) | −2.47 (−13.11, 8.17) |
| cg26083458 | 0.05 (−0.85, 0.95) | −7.73 (−24.27, 8.81) | 2.66 (−12.44, 17.75) | 0.26 (−0.41, 0.93) | 6.29 (−11.56, 24.13) | −3.56 (−16.92, 9.80) |
| cg13638257 | −0.30 (−1.49, 0.89) | −0.84 (−21.85, 20.16) | 5.82 (−13.21, 24.86) | −0.08 (−0.92, 0.77) | 15.05 (−7.33, 37.44) | 0.59 (−16.32, 17.51) |
| cg05700142 | 0.21 (−0.47, 0.89) | −5.47 (−18.17, 7.23) | 3.65 (−7.91, 15.21) | 0.05 (−0.44, 0.53) | 9.61 (−3.29, 22.51) | −0.77 (−10.54, 9.00) |
| cg01654446 | 0.06 (−0.68, 0.81) | −2.96 (−17.24, 11.32) | 3.64 (−9.31, 16.60) | −0.28 (−0.74, 0.17) | 4.56 (−8.46, 17.57) | 4.15 (−5.56, 13.86) |
| cg18930100 | −0.24 (−1.44, 0.97) | −3.94 (−26.46, 18.58) | 3.09 (−17.37, 23.55) | −0.58 (−1.47, 0.31) | 24.21 (−1.16, 49.57) | 7.93 (−11.37, 27.22) |
| cg06230948 | −0.13 (−0.60, 0.34) | 9.54 (1.16, 17.93) | 0.38 (−7.47, 8.23) | 0.17 (−0.13, 0.47) | 8.11 (0.29, 15.95) | 3.87 (−2.07, 9.81) |
| cg08814531 | −0.43 (−2.07, 1.21) | 3.80 (−26.09, 33.69) | 20.99 (−5.77, 47.75) | −0.01 (−1.11, 1.09) | 4.76 (−23.05, 32.57) | 0.15 (−20.65, 20.95) |
| cg03591496 | −1.26 (−2.61, 0.28) | 8.55 (−18.60, 35.70) | 14.88 (−9.63, 39.38) | −0.28 (−1.28, 0.73) | 18.04 (−6.87, 42.96) | 7.18 (−11.61, 25.98) |
| cg20973878 | 0.92 (−0.72, 2.56) | −13.86 (−43.11, 15.40) | −20.93 (−47.25, 5.38) | – | – | – |
| cg27020289 | −0.78 (−2.26, 0.70) | 16.46 (−12.31, 45.23) | 1.23 (−25.11, 27.57) | – | – | – |
| cg00274587 | −0.29 (−1.60, 1.03) | −3.05 (−24.47, 18.37) | −5.59 (−25.02, 13.84) | – | – | – |
| cg00558147 | 0.09 (−1.49, 1.68) | 6.69 (−19.27, 32.65) | 9.95 (−13.56, 33.47) | – | – | – |
| cg00792719 | 0.92 (−0.59, 2.43) | 11.61 (−16.31, 39.53) | −16.99 (−42.17, 8.20) | – | – | – |
| cg07500019 | 0.00 (−1.76, 1.76) | 1.67 (−30.75, 34.09) | −8.62 (−38.01, 20.77) | – | – | – |
| cg07955457 | −0.12 (−1.48, 1.25) | 23.49 (0.03, 46.96) | 18.71 (−2.72, 40.15) | – | – | – |
| cg27385940 | −0.69 (−3.58, 2.20) | −1.88 (−13.38, 9.62) | −3.68 (−14.10, 6.74) | – | – | – |
a Adjusted for maternal age at delivery, race/ethnicity, maternal pre-pregnancy obesity, and smoking status during pregnancy.
bAll CpG sites listed are located in Chromosome 6.
cCpG sites listed were all associated with maternal pre-pregnancy BMI after accounting for multiple testing (q < 0.05). Associations between TAPBP gene CpGs and offspring BMI z-score and elevated blood pressure were not statistically significant after applying the Bonferroni test for multiple testing (female offspring p < 0.002 for 28 tests; male offspring p < 0.003 for 17 tests).
dCpGs were all located in the gene body of the TAPBP gene
Bold represents associations with p < 0.05.