Table 4.
Top longitudinal changes in methylation in PD cases.
| Probe ID | Chr | Position | Gene ID | Change rate PD |
Pvalue PD |
Change rate Controls | Pvalue Controls |
|---|---|---|---|---|---|---|---|
| Methylation decreasing over time | |||||||
| cg26275301 | chr17 | 81041828 | METRNL | −0.604 | 7.56E-08 | −0.00026 | 6.93E-01 |
| cg07856430 | chr18 | 42339206 | N/A | −0.525 | 8.67E-09 | −0.00058 | 2.85E-01 |
| cg13153353 | chr7 | 4175865 | SDK1 | −0.524 | 5.43E-08 | 0.00244 | 2.30E-05 |
| cg03565777 | chr12 | 125028339 | NCOR2 | −0.508 | 8.40E-08 | −0.00276 | 1.38E-06 |
| cg24136431 | chr19 | 47016623 | N/A | −0.392 | 6.40E-08 | −0.00045 | 2.93E-01 |
| cg16655626 | chr19 | 45886078 | N/A | −0.334 | 2.46E-09 | 0.00152 | 4.38E-01 |
| cg04843111 | chr1 | 156617074 | BCAN | −0.328 | 1.00E-09 | −0.00088 | 6.64E-01 |
| cg08988821 | chr7 | 74075293 | GTF2I | −0.326 | 4.22E-08 | −0.00107 | 6.71E-01 |
| cg01791421 | chr1 | 19996240 | N/A | −0.309 | 8.38E-08 | −0.00105 | 2.19E-03 |
| cg13994376 | chr13 | 112554122 | LINC00354 | −0.292 | 1.25E-08 | 0.00005 | 8.71E-01 |
| cg15987655 | chr5 | 139196457 | N/A | −0.278 | 5.86E-08 | −0.00285 | 1.42E-01 |
| cg03389720 | chr16 | 8780048 | ABAT | −0.277 | 2.00E-08 | −0.00091 | 1.88E-03 |
| cg15765398 | chr21 | 46409994 | LINC00163 | −0.272 | 5.57E-09 | −0.00114 | 4.16E-01 |
| cg09750643 | chr11 | 1718086 | KRTAP5 | −0.257 | 8.04E-09 | −0.00022 | 4.07E-01 |
| Methylation increasing over time | |||||||
| cg17046825 | chr13 | 21081216 | N/A | 0.834 | 5.35E-08 | −0.00311 | 6.60E-04 |
| cg26126295 | chr4 | 119095240 | N/A | 0.775 | 1.78E-08 | 0.00030 | 9.44E-01 |
| cg06688960 | chr20 | 1504932 | N/A | 0.713 | 1.04E-09 | −0.00053 | 8.49E-01 |
| cg25979148 | chr4 | 871629 | N/A | 0.210 | 2.55E-08 | −0.00001 | 9.95E-01 |
| cg15540764 | chr7 | 36919658 | ELMO1 | 0.140 | 7.33E-08 | −0.00040 | 9.61E-03 |
| cg05933219 | chr2 | 240099221 | HDAC4 | 0.134 | 5.61E-08 | −0.00058 | 4.87E-01 |
| cg14946911 | chr20 | 56772325 | N/A | 0.128 | 2.24E-09 | 9.91E-06 | 9.90E-01 |
| cg09593391 | chr8 | 144737908 | ZNF623 | 0.126 | 9.53E-08 | −0.00017 | 8.51E-01 |
| cg18496624 | chr17 | 38094692 | N/A | 0.123 | 5.44E-09 | −0.00005 | 7.14E-01 |
| cg10401356 | chr8 | 140712424 | N/A | 0.123 | 1.11E-08 | 0.00037 | 6.62E-01 |
| cg08561469 | chr16 | 81944150 | PLCG2 | 0.116 | 3.38E-09 | 0.00002 | 8.52E-01 |
| cg15475168 | chr7 | 101860421 | N/A | 0.115 | 1.16E-08 | −0.00023 | 7.69E-01 |
| cg20397902 | chr16 | 88624807 | N/A | 0.109 | 1.06E-08 | −0.00023 | 7.43E-01 |
| cg01202950 | chr15 | 74943647 | EDC3 | 0.106 | 6.20E-09 | −0.00027 | 6.90E-01 |
Name indicates probe designation at Illumina EPIC human methylation array; Chr is chromosome location of the CG; position refers to Genome Reference Consortium Human Build 37 (GRCh37) hg19; N/A indicates no annotated gene associated with the probe. Rate of change indicates percentage methylation change/year.