Table 6.
Longitudinal changes in methylation in PD cases NOT receiving L-dopa/entacapone.
| Probe ID | Chr | Position | Gene ID |
Change rate PD No Med |
Pvalue PD |
Change rate Controls |
Pvalue Controls |
|---|---|---|---|---|---|---|---|
| Methylation decreasing over time | |||||||
| cg14952312 | chr17 | 72350710 | KIF19 | −1.537 | 2.41E-09 | −0.00156 | 6.41E-01 |
| cg18812198 | chr11 | 68715658 | N/A | −1.324 | 7.66E-08 | 0.00114 | 6.95E-01 |
| cg15969149 | chr10 | 77352287 | N/A | −1.054 | 1.61E-08 | 0.00087 | 7.34E-01 |
| cg15531997 | chr10 | 34999169 | N/A | −0.981 | 5.39E-12 | 0.00023 | 8.71E-01 |
| cg19174044 | chr20 | 18446362 | DZANK1 | −0.914 | 3.71E-08 | 0.00091 | 6.32E-01 |
| cg13937758 | chr6 | 150217448 | RAET1E | −0.711 | 3.55E-08 | −0.00227 | 1.83E-01 |
| Methylation increasing over time | |||||||
| cg14771419 | chr7 | 142012988 | TRBV4 | 1.713 | 1.03E-09 | −0.00114 | 7.31E-01 |
| cg16134323 | chr5 | 140562034 | PCDHB16 | 1.507 | 7.50E-10 | −0.00042 | 8.29E-01 |
| cg13252209 | chr16 | 51603716 | N/A | 1.279 | 1.78E-08 | −0.00192 | 5.70E-01 |
| cg03700944 | chr6 | 46703468 | PLA2G7 | 1.093 | 8.90E-09 | −0.00262 | 2.94E-01 |
| cg06688960 | chr20 | 1504932 | N/A | 0.988 | 3.41E-08 | −0.00053 | 8.49E-01 |
| cg26421310 | chr1 | 25257058 | RUNX3 | 0.093 | 2.43E-08 | −0.00055 | 3.31E-03 |
| cg27380788 | chr16 | 4526765 | NMRAL1 | 0.073 | 9.24E-08 | −0.00046 | 2.78E-03 |
| cg11107196 | chr16 | 71918265 | ZNF821 | 0.065 | 5.36E-09 | −0.00019 | 1.37E-01 |
| cg09585751 | chr6 | 24646282 | KIAA0319 | 0.056 | 9.21E-08 | −0.00021 | 4.51E-02 |
| cg14934866 | chr16 | 29985156 | TAOK2 | 0.053 | 7.30E-08 | −0.00023 | 7.87E-02 |
| cg21645604 | chr6 | 36098567 | MAPK13 | 0.043 | 3.31E-08 | −0.00014 | 5.70E-02 |
| cg07038191 | chr16 | 29801882 | KIF22 | 0.041 | 5.83E-08 | −0.00028 | 3.27E-04 |
| cg23993697 | chr11 | 9685562 | SWAP70 | 0.04 | 7.05E-08 | −0.00012 | 2.22E-01 |
| cg17129217 | chr9 | 91933717 | SECISBP2 | 0.039 | 6.52E-08 | −0.00022 | 5.45E-03 |
| cg15193793 | chr14 | 90422250 | EFCAB11 | 0.038 | 8.37E-08 | −0.00012 | 2.83E-01 |
| cg19116545 | chr3 | 138313166 | CEP70 | 0.037 | 3.02E-08 | −0.00022 | 8.33E-03 |
| cg18104674 | chr18 | 60190218 | ZCCHC2 | 0.036 | 5.58E-08 | −0.00011 | 9.65E-02 |
| cg20390702 | chr12 | 8850385 | RIMKLB | 0.036 | 6.54E-08 | −0.00019 | 1.85E-02 |
Name indicates probe designation at Illumina EPIC human methylation array; Chr is chromosome location of the CG; position refers to Genome Reference Consortium Human Build 37 (GRCh37) hg19; N/A indicates no annotated gene associated with the probe. Rate of change indicates percentage methylation change/year. N/A indicates no annotated gene associated with the probe.