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. 2019 Jun 4;13(1):172–191. doi: 10.1080/19336950.2019.1619436

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Comparative TRPV1 responses to different cannabinoids. A.

Current development over time (Imax, outward) for HEK-TRPV1 exposed for 120 s, starting at 60 s and ending at 180 s, to the indicated cannabinoids of CBD (closed circle), CBDV (open circle), CBN (asterisk) and CBG (cross). The color code for cannabinoid dose were: at 150 µM (red), 50 µM (green) and 30 µM (yellow). Panel B. data as in (A) by compound and by dose, individual; responses showing inward currents (from −80 mV) and outward currents (from +80 mV). C. Histogram summary of Imax data from (B). Recording conditions were NaR, Ca 1 mM with unbuffered internal calcium (Fca) and the n determinations varied from 5 to 8 patches and as indicated in panel C, bar graphs.