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. 2019 Jun 4;13(1):172–191. doi: 10.1080/19336950.2019.1619436

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Two state nature of TRPV1. Panels A-D.

Dose-dependent attainment of pore-dilated state by TRPV1 in response to Capsaicin. A. Current development over time with the indicated Capsaicin doses. B. Extracted I/V curves showing transition from rectifying to non-rectifying state with increasing dose/current amplitude. C. Histogram summary of inward and outward current portions per dose. Histogram data confirm that linearized I/V relationship corresponds to pore-dilated state by demonstrating increased Na current amplitude. Current development relationships (D) suggest some pore-dilation (NMDG sensitivity) even at the lowest Capsaicin doses. Current/voltage relationships (E) and I max histograms for sodium and NMDG permeation (F) illuminate the distinct states.