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. 2019 Jun 4;13(1):172–191. doi: 10.1080/19336950.2019.1619436

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Examination of pore-dilation in Cannabinoid-evoked TRPV1 currents.

A, B. Driving large CBD-evoked currents through extended tetracycline induction time (current development graphs shown in A for tetracycline inductions of 0–13 h) does not translate to attainment of a non-rectifying pore-dilated state for the conductance (B). C. Currents evoked by CBD and Capsaicin of similar amplitudes are distinguished by their current/voltage relationships. Induction time of 25 h with CBD doses of 50 μM followed by 1 μM Capsaicin. I/V relationships (D) show that CBD-evoked currents are rectified while Capsaicin-evoked current is highly linear. E, F, G. H. Protocol as in Figure 7 A-D but with CBDV (E, F) or CBG (G, H).