Figure 1.

Replication of associations between DNA methylation in blood and CRP and other circulating inflammatory markers. Each point represents the beta coefficient for a previously reported association between an inflammatory marker and methylation at a CpG site (y-axis) in relation to the beta coefficient for the same association in the current study (x-axis). In (a) Ligthart et al. [9], methylation values were modelled as the outcome, and in (b) Ahsan et al. [10], methylation values were modelled as the exposure. The red line represents an estimated regression line. NPX: Normalized protein expression.