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. 2019 Apr 29;14(7):649–659. doi: 10.1080/15592294.2019.1603962

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Average within-individual age trajectories for CpG methylation levels. The CpG sites shown demonstrated an association between methylation and levels of an inflammatory protein (in square brackets on the y-axis), as well as a significant change over time (P < 0.0005). Average within-individual age trajectories were estimated in mixed models, including interaction terms between age and the mean protein levels over the two measurements. Marginal effects, depicted as regression lines, were estimated for ages 30 to 60 by the 10^th, 50^th, and 90^th percentiles of the mean inflammatory protein levels.