Table 3.
Top 20 differentially methylated genomic regions identified between case and control groups.
| Chr. position | Gene ID | Gene name/function | > Meth | p-Value | Q value | Fold diff | Genic region | CpG island region |
|---|---|---|---|---|---|---|---|---|
| Chr3. 33,439,984 | UBP1 | Upstream Binding Protein 1/transcriptional activator, angiogenesis, blood pressure | Case | 9.46E-06 | 0.0002 | 2.45 | on_exon | InterCpG |
| Chr13. 31,183,198 | HSPH1 | Heat Shock Protein Family H (Hsp110) Member 1/inhibits aggregation of misfolded proteins, stress response | Case | 3.52E-05 | 0.0004 | 1.05 | 3’UTR | InterCpG |
| Chr3. 13,290,659 | HDAC11 | Histone Deacetylase 11 | Case | 3.7E-05 | 0.0004 | 1.03 | 5ʹUTR | InterCpG |
| Chr19. 55,359,429 | FAM71E2 | Family with Sequence Similarity 71 Member E2 | Case | 4.02E-05 | 0.0004 | 1.08 | on_exon | InterCpG |
| Chr3. 100,417,592 | LNP1 | Leukaemia NUP98 Fusion Partner 1 | Case | 0.0001 | 0.0006 | 1.03 | on_intron | InterCpG |
| Chr14. 32,115,522 | ARHGAP5 | Rho GTPase Activating Protein 5/endothelial cytoskeleton and permeability | Case | 0.0001 | 0.0008 | 1.04 | on_intron | InterCpG |
| Chr3. 87,375,514 | POU1F1 | POU Class 1 Homeobox 1/transcription factor, growth and development | Case | 0.0001 | 0.0008 | 1.04 | 3’UTR | InterCpG |
| Chr9. 80,344,759 | SPATA31D4 | SPATA31 Subfamily D Member 4/may play a role in spermatogenesis. | Case | 0.0002 | 0.00010 | 1.06 | 5’UTR | InterCpG |
| Chr7. 90,497,286 | CLDN12 | Claudin 12/tight junction protein | Case | 0.0002 | 0.00010 | 1.02 | on_intron | InterCpG |
| Chr11. 3,204,666 | OSBPL5 | Oxysterol Binding Protein Like 5 | Control | 8.58E-06 | 0.0001 | 1.19 | 3ʹUTR | CpGI_shore |
| Chr8. 144,327,288 | DGAT1 | Diacylglycerol O-Acyltransferase 1 | Control | 9.96E-06 | 0.0002 | 1.65 | 3ʹUTR | CpGI_core |
| Chr22. 37,828,716 | EIF3L | Eukaryotic Translation Initiation Factor 3 Subunit L | Control | 1.13E-05 | 0.0002 | 1.07 | 5’UTR | InterCpG |
| Chr14. 99,831,302 | EML1 | Echinoderm Microtubule Associated Protein Like 1/recognition of histone marks | Control | 1.17E-05 | 0.0002 | 1.05 | on_intron | InterCpG |
| Chr4. 4,227,293 | OTOP1 | Otopetrin 1 | Control | 1.24E-05 | 0.0003 | 1.28 | 3’UTR | CpGI_core |
| Chr3. 51,713,043 | GRM2 | Glutamate Metabotropic Receptor 2 | Control | 1.92E-05 | 0.0003 | 1.04 | on_exon | InterCpG |
| Chr20. 43,655,560 | MYBL2 | MYB Proto-Oncogene Like 2 | Control | 0.0001 | 0.0004 | 1.03 | 5ʹUTR | InterCpG |
| Chr20. 64,057,589 | SOX18 | SRY-Box 18/cardiomyogenesis, endothelial angiogenic function | Control | 0.0001 | 0.0008 | 1.58 | 3’UTR | InterCpG |
| Chr11. 61,752,535 | MYRF | Myelin Regulatory Factor | Control | 0.0001 | 0.0009 | 1.48 | 5ʹUTR | CpGI_core |
| Chr20. 62,134,895 | LSM14B | LSM Family Member 14B | Control | 0.0001 | 0.0009 | 1.11 | on_intron | InterCpG |
| Chr9. 72,060,140 | C9orf57 | Chromosome 9 Open Reading Frame 57 | Control | 0.0002 | 0.0009 | 1.02 | on_intron | InterCpG |