Table 2.
CpGs significant in ever/nevera analysis and at least one trend test.
| Probe | CHR | Gene/Location | Ever/Never |
Duration of use |
Recency of use |
|||
|---|---|---|---|---|---|---|---|---|
| p-value | q-value | p-value | q-value | p-value | q-value | |||
| cg01382688 | 2 | ARHGEF4 | 3.7E-08 | 0.01 | 2.7E-06 | 0.03 | 4.3E-06 | 0.04 |
| cg26334888 | 3 | FAM3D | 7.3E-08 | 0.01 | 2.7E-04 | 0.09 | 1.2E-08 | 0.00 |
| cg03472655 | 1 | SH2D5 | 9.1E-08 | 0.01 | 1.9E-04 | 0.08 | 2.4E-06 | 0.04 |
| cg08460153 | 7 | TNRC18 | 2.5E-07 | 0.01 | 1.4E-05 | 0.04 | 4.8E-07 | 0.02 |
| cg11034191 | 4 | INPP4B | 4.3E-07 | 0.01 | 3.1E-09 | 0.00 | 6.3E-06 | 0.05 |
| cg16416165 | 4 | RGS12 | 4.6E-07 | 0.01 | 2.3E-05 | 0.05 | 6.9E-06 | 0.05 |
| cg09180239 | 16 | GSE1 | 8.2E-07 | 0.02 | 1.1E-05 | 0.04 | 3.3E-05 | 0.07 |
| cg11151929 | 3 | LRRC58 | 1.1E-06 | 0.02 | 2.0E-07 | 0.01 | 6.5E-05 | 0.08 |
| cg09423413 | 6 | TRIM40 | 1.3E-06 | 0.02 | 5.1E-06 | 0.03 | 1.5E-04 | 0.10 |
| cg19049616 | 17 | RNFT1 | 1.4E-06 | 0.02 | 1.0E-04 | 0.07 | 1.9E-06 | 0.03 |
| cg15028339 | 5 | RAI14 | 1.7E-06 | 0.02 | 7.3E-06 | 0.03 | 5.1E-07 | 0.02 |
| cg01571735 | 2 | SP5 | 2.2E-06 | 0.02 | 1.9E-05 | 0.04 | 6.1E-06 | 0.05 |
| cg06133876 | 6 | PBOV1 | 2.4E-06 | 0.02 | 2.2E-05 | 0.05 | 2.3E-05 | 0.07 |
| cg18291238 | 14 | 14q24 | 2.5E-06 | 0.02 | 3.4E-04 | 0.09 | 3.2E-06 | 0.04 |
| cg04763519 | 6 | 6p25 | 4.0E-06 | 0.02 | 1.5E-04 | 0.07 | 5.3E-07 | 0.02 |
| cg17771569 | 19 | ATP8B3 | 4.6E-06 | 0.02 | 1.5E-05 | 0.04 | 2.7E-04 | 0.11 |
| cg01953797 | 8 | GPIHBP1 | 5.2E-06 | 0.02 | 1.9E-05 | 0.05 | 4.0E-05 | 0.07 |
| cg17472832 | 2 | PROM2 | 5.6E-06 | 0.03 | 1.4E-05 | 0.04 | 1.3E-05 | 0.06 |
| cg12542656 | 2 | NA | 5.6E-06 | 0.03 | 2.2E-08 | 0.00 | 8.6E-05 | 0.09 |
| cg07273415 | 11 | CYB561A3 | 6.1E-06 | 0.03 | 2.7E-06 | 0.03 | 7.5E-06 | 0.05 |
| cg08030662 | 17 | KIF2B | 6.3E-06 | 0.03 | 1.1E-04 | 0.07 | 5.7E-08 | 0.01 |
| cg26705583 | 5 | SGTB | 7.6E-06 | 0.03 | 3.1E-05 | 0.05 | 6.7E-08 | 0.01 |
| cg00099017 | 16 | RBFOX1 | 8.5E-06 | 0.03 | 5.0E-03 | 0.21 | 1.0E-06 | 0.03 |
| cg08274097 | 19 | ZNF607 | 9.1E-06 | 0.03 | 7.0E-03 | 0.22 | 1.7E-06 | 0.03 |
| cg04671476 | 5 | MGAT1 | 9.3E-06 | 0.03 | 1.4E-05 | 0.04 | 3.1E-05 | 0.07 |
| cg25640096 | 6 | NA | 1.2E-05 | 0.03 | 6.5E-07 | 0.02 | 3.8E-05 | 0.07 |
| cg08255481 | 16 | BANP | 1.3E-05 | 0.03 | 9.2E-06 | 0.04 | 4.4E-04 | 0.12 |
| cg13030786 | 7 | TNRC18 | 1.3E-05 | 0.03 | 4.7E-04 | 0.10 | 5.9E-06 | 0.05 |
| cg15437133 | 10 | ZNF503-AS2 | 1.3E-05 | 0.03 | 2.5E-07 | 0.01 | 3.1E-05 | 0.07 |
| cg06194738 | 6 | GPSM3 | 1.4E-05 | 0.03 | 1.6E-04 | 0.08 | 6.3E-06 | 0.05 |
| cg24290251 | 7 | 7p15 | 1.5E-05 | 0.03 | 1.0E-03 | 0.14 | 9.0E-07 | 0.03 |
| cg26791665 | 1 | ALDH4A1 | 1.7E-05 | 0.03 | 5.0E-06 | 0.03 | 8.6E-05 | 0.09 |
| cg00352027 | 10 | AIFM2 | 1.8E-05 | 0.03 | 9.0E-04 | 0.12 | 2.3E-06 | 0.04 |
| cg27269561 | 16 | THOC6 | 1.8E-05 | 0.03 | 3.3E-05 | 0.05 | 2.4E-04 | 0.11 |
| cg14415844 | 14 | CCDC88C | 1.9E-05 | 0.03 | 6.8E-06 | 0.03 | 2.1E-04 | 0.10 |
| cg14662522 | 4 | NA | 2.1E-05 | 0.04 | 4.3E-07 | 0.01 | 2.0E-03 | 0.19 |
| cg26185079 | 18 | SLMO1 | 2.3E-05 | 0.04 | 1.2E-05 | 0.04 | 1.0E-06 | 0.03 |
| cg08048620 | 17 | TTYH2 | 2.5E-05 | 0.04 | 1.0E-06 | 0.02 | 0.0E+00 | 0.07 |
| cg06538238 | 6 | GABBR1 | 2.6E-05 | 0.04 | 2.3E-04 | 0.08 | 5.0E-07 | 0.02 |
| cg09413013 | 17 | TMC8 | 2.7E-05 | 0.04 | 6.4E-06 | 0.03 | 2.6E-05 | 0.07 |
| cg09071838 | 13 | CENPJ | 2.8E-05 | 0.04 | 2.2E-05 | 0.05 | 2.0E-04 | 0.10 |
| cg03606898 | 19 | NA | 3.0E-05 | 0.04 | 2.9E-05 | 0.05 | 2.5E-04 | 0.11 |
| cg25140751 | 15 | CIB2 | 3.3E-05 | 0.04 | 4.8E-06 | 0.03 | 8.8E-05 | 0.09 |
| cg26279783 | 6 | COL11A2 | 3.5E-05 | 0.04 | 1.8E-05 | 0.04 | 5.1E-04 | 0.13 |
| cg09742643 | 7 | PTPRN2 | 3.5E-05 | 0.04 | 1.1E-05 | 0.04 | 1.6E-06 | 0.03 |
| cg08975834 | 10 | TCERG1L | 3.7E-05 | 0.04 | 9.5E-06 | 0.04 | 8.8E-07 | 0.03 |
| cg26365623 | 11 | 11p15 | 3.8E-05 | 0.04 | 5.6E-02 | 0.40 | 3.8E-06 | 0.04 |
| cg19793640 | 21 | SH3BGR | 4.0E-05 | 0.04 | 2.0E-03 | 0.14 | 5.9E-06 | 0.05 |
| cg25044701 | 12 | GDF3 | 4.3E-05 | 0.05 | 1.1E-05 | 0.04 | 8.0E-05 | 0.08 |
| cg02601249 | 2 | 2p12 | 4.6E-05 | 0.05 | 4.0E-03 | 0.19 | 4.7E-06 | 0.04 |
| cg06362313 | 12 | GAPDH | 5.0E-05 | 0.05 | 5.8E-08 | 0.01 | 1.4E-04 | 0.10 |
| cg01360281 | 5 | NA | 5.0E-05 | 0.05 | 1.0E-05 | 0.04 | 4.0E-03 | 0.22 |
| cg16518142 | 20 | CDH26 | 5.1E-05 | 0.05 | 2.0E-03 | 0.15 | 3.0E-06 | 0.04 |
| cg03902160 | 1 | PTPRU | 5.2E-05 | 0.05 | 3.0E-07 | 0.01 | 1.9E-05 | 0.07 |
| cg02245004 | 15 | 15q24 | 5.4E-05 | 0.05 | 2.8E-06 | 0.03 | 1.9E-06 | 0.03 |
| cg06894891 | 14 | TPPP2 | 5.4E-05 | 0.05 | 5.6E-05 | 0.06 | 4.4E-06 | 0.04 |
| cg20677939 | 6 | ARID1B | 5.4E-05 | 0.05 | 2.8E-06 | 0.03 | 1.1E-05 | 0.06 |
| cg11847964 | 12 | NA | 5.5E-05 | 0.05 | 3.3E-06 | 0.03 | 3.7E-04 | 0.12 |
| cg23697855 | 7 | NA | 5.6E-05 | 0.05 | 2.8E-06 | 0.03 | 1.0E-03 | 0.16 |
| cg18072095 | 5 | C5orf30 | 6.1E-05 | 0.05 | 2.0E-03 | 0.15 | 6.9E-06 | 0.05 |
| cg00274357 | 8 | PUF60 | 6.6E-05 | 0.05 | 7.4E-06 | 0.03 | 1.0E-02 | 0.29 |
| cg02861082 | 2 | MCM6 | 6.8E-05 | 0.05 | 9.5E-06 | 0.04 | 1.4E-04 | 0.10 |
| cg09100343 | 16 | CPNE2 | 7.0E-05 | 0.05 | 6.4E-06 | 0.03 | 2.3E-04 | 0.11 |
| cg19216162 | 20 | C20orf24 | 7.3E-05 | 0.05 | 3.4E-06 | 0.03 | 6.3E-04 | 0.14 |
| cg26098117 | 6 | 6q22 | 7.6E-05 | 0.05 | 4.4E-06 | 0.03 | 3.9E-06 | 0.04 |
| cg17045804 | 5 | NPR3 | 7.8E-05 | 0.05 | 1.0E-05 | 0.04 | 2.5E-04 | 0.11 |
| cg03836747 | 7 | NA | 7.9E-05 | 0.05 | 7.8E-06 | 0.03 | 5.0E-03 | 0.23 |
| cg24141382 | 1 | CTPS1 | 8.0E-05 | 0.05 | 4.5E-06 | 0.03 | 1.0E-03 | 0.16 |
a Adjusted for: age at surgery, race (White, Black, Other), reason for surgery (invasive cancer, in situ cancer, benign, prophylactic, reduction) and BMI (treated as a continuous variable)