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. 2019 Apr 13;14(6):545–557. doi: 10.1080/15592294.2019.1595997

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Proposed mechanism of a miRNA binding site acting as a sponge for miR-221/222. The seed sequence 1 encompasses the rs17084733. (Upper panel) The sequence with WT (TT) allele acts like a sponge, soaking up miR-221/222 and therefore, reducing their availability for sites 2 and 3. (Lower panel) Presence of the rs17085733 variant allele (TA or AA) disrupts the sponge site, increasing miR-221/222 availability for sites 2 and 3. Overall, disruption of the sponge contributes to repress KIT expression.