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. 2019 Apr 22;14(6):611–622. doi: 10.1080/15592294.2019.1605816

Figure 2.

Figure 2.

DNA methyltransferases expression during embryogenesis measured by real-time qRT-PCR. Gene expressions in all the embryonic stages were normalized against expression in sperm (set as 1), RQ: Relative quantification. (a): DNMT1, one-way ANOVA analysis showed p < 0.0001, Tukey’s multiple comparisons test showed significant differences between Oocyte to blastula stages vs. Sperm, gastrula stages and Early neurula. (b): DNMT3AA, one-way ANOVA analysis showed no significant differences among examined stages. (c): DNMT3BA, one-way ANOVA analysis showed p < 0.0001, Tukey’s multiple comparisons test showed significant differences between Early gastrula vs. all other examined stages. (d): DNMT3BB.1, one-way ANOVA analysis showed p < 0.0001, Tukey’s multiple comparisons test showed significant differences between 16-cell, Late blastula vs. Sperm, Oocyte, Zygote, Mid gastrula, Late gastrula, and Early neurula. (e): A relationship between DNMT3BB.1 expression and global 5-mC levels. Data represent mean ± SEM. Asterisk indicates statistical significance (**p < 0.01, ***p < 0.001).