. Author manuscript; available in PMC: 2019 Jun 10.

Published in final edited form as: Clin Chem Lab Med. 2014 Jan 1;52(1):21–32. doi: 10.1515/cclm-2013-0174

Table 4.

HbA_1c as a 10-year prospective risk factor of complications: effect of adjustment for skin collagen AGE.

Complication^a	Risk marker	Before adjustment for AGE	After adjustment for AGE^b
Retinopathy	DCCT mean A_1c	<0.0001	NS: Furosine
			NS: Furosine and CML
			<0.0001: CML
	EDIC mean A_1c	<0.0001	<0.0001: Furosine, CML
			<0.0001: Furosine
			<0.0001: CML
Nephropathy	DCCT mean A_1c	0.0012	NS: Furosine:
Nephropathy	DCCT mean A_1c	<0.0001	NS: Furosine and CML
	DCCT mean A_1c, log AER	0.0002	0.0287: CML
	DCCT mean A_1c, log AER	0.0002	0.0046 (Furosine, CML)
	EDIC mean A_1c	<0.0001	<0.0001: Furosine, CML
			<0.0001: Furosine
			<0.0001: CML
Neuropathy	DCCT A_1c	N/A	N/A
Neuropathy	EDIC A_1c	N/A	N/A

For complication subcategories, consult original publication.

A significant p-value indicates the adjustment has no impact on the association. N/A, not available. NS, not significant.