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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Am J Med Genet A. 2019 May 14;179(7):1122–1125. doi: 10.1002/ajmg.a.61179

Figure 1:

Figure 1:

Pedigree and brain MRI of a subject with SPG35. A) Pedigree of the family showing affected individuals in the branch with consanguinity. Asterisks indicating those seen in clinic. Brain MRI of the oldest living patient showing B) T1 signal: thin corpus callosum (black arrow), and cerebellar atrophy (red arrow), and C) T2 FLAIR: periventricular leucodystrophy (black arrow). D) Patient photographs showing spasticity with scissor legs.