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. 2019 Apr 29;67(8):1571–1597. doi: 10.1002/glia.23630

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© 2019 The Authors. Glia published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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HBEGF inhibits astrocyte maturation. (a) Astrocytes were treated with or without 5 ng/mL HBEGF. The expression of Gja1 and Aqp4 were determined by qRT‐PCR and normalized to the expression of the housekeeping gene, Gapdh. (b) Volcano plot showing differential gene expression under HBEGF withdrawal conditions. Q‐value is the p value adjusted for multiple comparisons using the EdgeR‐Limma‐Voom package in R. (c) Top gene ontology terms enriched in up‐ or down‐regulated genes under HBEGF withdrawal conditions [Color figure can be viewed at wileyonlinelibrary.com]