Fig. 3.

Forest plot and meta-analysis across the discovery, older adult (> 40 years), smokers with a substantial smoking history, individuals with non-restrictive spirometry pattern, and stratified smoking status datasets from the Generation Scotland: Scottish Family Health Survey (GS:SFHS) cohort for differentially methylated sites associated with FVC and FEV₁/FVC that showed high heterogeneity in older adults and across the smoking strata. The sizes of the forest plot squares are proportional to the amount of information each dataset contains. Key: All, discovery data; >40, data from participants aged 40 or greater; >10py, data from participants with a smoking history of 10 pack years or greater.