Table 1.
Characteristics of Generation Scotland: Scottish Family Health Survey (GS:SFHS) participants (n = 3781) in the epigenome-wide association study discovery population.
| Spirometry data |
||||
|---|---|---|---|---|
| COPD cases (n = 274) | Controls (n = 2919) | GOLD stage 1 (n = 588) | Missing (n = 905) | |
| Characteristics | ||||
| Age, years | 53.96 ± 13.59 | 46.98 ± 13.37 | 52.15 ± 12.75 | 49.58 ± 15.56 |
| Sex | ||||
| – Male | 93 (33.9) | 1162 (39.8) | 222 (37.8) | 335 (37.0)) |
| – Female | 181 (66.1) | 1757 (60.2) | 366 (62.2) | 570 (63.0) |
| Height, cm | 166.39 ± 8.76 | 167.85 ± 9.08 | 166.98 ± 9.47 | 166.22 ± 9.75 |
| Weight, kg | 73.50 ± 15.63 | 75.82 ± 16.33 | 76.60 ± 16.87 | 75.24 ± 17.45 |
| Smoking status | ||||
| – Never | 96 (35.0) | 1603 (55.0) | 249 (42.4) | 388 (42.9) |
| – Former (quit >12 months) | 74 (27.0) | 715 (24.5) | 164 (27.9) | 242 (26.8) |
| – Former (quit <12 months) | 3 (1.1) | 88 (3.0) | 20 (3.4) | 31 (3.5) |
| – Current | 89 (32.5) | 443 (15.1) | 133 (22.6) | 206 (22.8) |
| – Missing records | 12 (4.4) | 70 (2.4) | 22 (3.7) | 25 (2.8) |
| Pack-year | ||||
| – Former smokers (quit >12 months) | 25.47 ± 31.84 | 16.67 ± 20.31 | 22.83 ± 22.85 | 22.83 ± 22.87 |
| – Former smokers (quit <12 months) | 30.00 ± 31.05 | 15.16 ± 15.76 | 18.35 ± 20.20 | 18.35 ± 20.20 |
| – Current smokers | 22.97 ± 19.15 | 15.71 ± 15.95 | 23.59 ± 16.85 | 23.59 ± 16.85 |
| Lung function | ||||
| – FEV1, litres/s | 2.01 ± 0.60 | 3.24 ± 0.76 | 2.58 ± 0.66 | – |
| – FVC, litres/s | 3.45 ± 0.93 | 4.07 ± 0.94 | 3.72 ± 1.08 | – |
| – FEV1/FVC | 0.59 ± 0.10 | 0.80 ± 0.06 | 0.71 ± 0.08 | – |
| – FEV1 percent predicted | 66.96 ± 11.44 | 99.56 ± 11.17 | 83.97 ± 12.98 | – |
| – FVC percent predicted | 89.90 ± 13.09 | 99.49 ± 11.90 | 94.93 ± 20.81 | – |
Abbreviations: COPD, Chronic obstructive pulmonary disease; FEV1, Forced expiratory volume in 1 s; FVC, Forced vital capacity. Figures shown are the mean ± standard deviation or n (%).