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Comparison of mouse and large animal models of HD.
| Transgene | Exon1 (1–67) Htt-150Q | N208-150Q | HD-KI pig | ||
|---|---|---|---|---|---|
| Species | Mouse | Monkey | Mouse | Pig | Pig |
| lifespan | Short life span 5–8 m | Embryonic or Postnatal death | Survive | Postnatal death | Survive and germline transmission |
| Neuropathology | Atrophy | Axonal degeneration | Not obvious | Apoptosis | axonal degeneration |
| Htt aggregates | Yes | Yes | Yes | Yes | Yes |
