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. 2019 Jun 10;9:8415. doi: 10.1038/s41598-019-44932-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nanofiber-expanded CD34⁺ cell therapy homed to the wound bed and improved re-epithelialization and granulation tissue formation. (A) GFP labeled nanofiber-expanded CD34⁺ cells were detected in wound bed at various time points. (B) Hematoxylin and eosin staining of wound sections of the animals with or without CD34⁺ stem cell therapy. Insets show higher magnification of the specific area. Arrowheads indicate epithelialization of the wound tissue.