Fig. 3.

Contribution of nitrergic transmission to EFS-evoked contractile and relaxant responses of common marmoset ileum. The effect of L-NAME on the EFS-evoked contractile and relaxation response of the normal, drug naive (a, c, e) and MPTP-treated (b, d, f) common marmoset ileum. L-NAME concentration dependently increased the phase-i contractile response in normal a but had no effect on the ilea of the MPTP-treated animals b. The phase-i and the phase-ii relaxation was concentration dependently inhibited by L-NAME in the normal c but in tissues from the MPTP-treated animals, EFS-evoked relaxation was absent d. The phase-iii contractile response in tissues from normal e and MPTP-treated f were similar in magnitude but L-NAME did not have any significant effect on the EFS-evoked responses. Each bar is the mean ± s.e.m. of n = 6. *P < 0.05; **P < 0.001