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. 2019 Jun 10;10:2536. doi: 10.1038/s41467-019-10450-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — MgRA-driven Mn-injection into CL and LH. a Top: the representative RARE anatomical image used to clarify the optical fiber location driven by MgRA for Mn injection in CC. Middle: the atlas overlapped RARE images to illustrate the fiber tip location at the CL. Eye cream is covering the craniotomy (magenta arrow). Bottom: enlarged image of fiber location. b T1-weighted MPRAGE image (Mdeft) showing enhanced signal from Mn injection site in the CC and CL with dose-dependency. c Top: the atlas overlapped RARE images to illustrate the fiber tip location at the LH, Bottom: enlarged image of fiber location. d T1-weighted MPRAGE image showing enhanced signal from Mn injection site in the LH with dose-dependency. e Sagittal view of RARE anatomical image and MPRAGE image after MnCl₂ solution injection. f T1-weighted MPRAGE image at 1 h and 1 h 40 min after the injection. g The analysis of MEMRI signal at no injection, 1 injection, 2 injection, and 3 injection times, as shown in (b, d) (n = 5 injection points from 3 animals). Error bars represent mean ± SD