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. 2019 Jun 10;9:166. doi: 10.1038/s41398-019-0495-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Novel object recognition memory was detected in WT for both the massed and spaced training conditions. Ts65Dn did not display novel object recognition in the massed training condition, whereas the spaced training condition yielded significant novel object recognition. a WT displayed significantly more time exploring the novel object than the familiar object, both when training trials were administered consecutively (massed: t_1,11 = 2.29, *p < 0.05), and when the three training trials were administered at 1 h intervals (spaced: t_1,10 = 2.31, *p < 0.05). b Ts65Dn did not display a significant difference between time spent exploring the novel object and time spent exploring the familiar object (massed: t_1,11 = 2.035, NS). Ts65Dn displayed significantly more time exploring the novel object than the familiar object when training trials were administered at 1 h intervals (spaced: t_1,11 = 3.60, *p < 0.01). c Spaced training trials significantly elevated the DI in Ts65Dn, as compared to the DI in Ts65Dn given massed training trials (*p < 0.05). Interaction between genotype and training condition was not significant