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. 2019 Jun 10;9:166. doi: 10.1038/s41398-019-0495-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–d Ts65Dn mice were not significantly impaired on rotarod performance, as measured by latency to fall from the accelerating rotarod, when compared to WT controls (Cohort 1: F_1,1 = 0.0037, NS; Cohort 2: F_1,1 = 1.57, NS). a Cohort 1 WT displayed similar motor learning curves when trained with massed versus spaced trials (F_1,22 = 0.336, NS). WT showed a significant effect of training day (F_2,44 = 45.8, p < 0.0001), and a significant interaction between massed versus spaced x training day (F_2,44= 6.03, p < 0.01). b Cohort 1 Ts65Dn displayed similar motor learning curves when trained with massed versus spaced trials (F_1,22 = 0.05, NS). Ts65Dn showed a significant effect of training day (F_2,44 = 23.2, p < 0.001), but no interaction between massed versus spaced x training day (F_2,44 = 0.613, NS). c Cohort 2 WT displayed similar motor learning curves when trained with massed versus spaced trials (F_1,23 = 0.112, NS). WT showed a significant effect of training day (F_2,46 = 15.6, p < 0.001), but no interaction between massed versus spaced x training day (F_2,46 = 2.24, NS). d Cohort 2 Ts65Dn displayed similar motor learning curves when trained with massed versus spaced trials (F_1,24 = 2.30, NS). Ts65Dn showed a significant effect of training day (F_2,48 = 84.1, p < 0.001), but no interaction between massed versus spaced x training day (F_2,48 = 0.116, NS). e–f Ube3a mice were significantly impaired on rotarod motor learning as compared to WT controls (F_1,1= 118.6, p < 0.001). e WT displayed similar motor learning curves when trained with massed versus spaced trials (F_1,22 = 0.044, NS). WT showed a significant effect of training day (F_2,44 = 25.2, p < 0.001), but no interaction between massed versus spaced x training day (F_2,44 = 1.02, NS). f Ube3a displayed similar motor learning curves when trained with massed versus spaced trials (F_1,22 = 1.47, NS). Ube3a showed a significant effect of training day (F_2,44 = 11.8, p < 0.001), but no interaction between massed versus spaced x training day (F_2,44 = 0.0874, NS)