Table 1.

Clinical characteristics, age group, sex, clinical manifest and sample source, PCV period.

Category	≤2	3–5	6–15	16–24	25–44	45–65	>65	Total
Total	7179	2790	1061	398	982	602	442	13,454
Sex
F	2863	972	440	214	502	173	89	5253
M	3288	1067	486	150	343	209	117	5660
Missing	1028	751	135	34	137	220	236	2541
Manifest
Carriage	2841	935	646	223	173	25	6	4849
Disease	4338	1855	415	175	809	577	436	8605
Source
Blood	2998	1234	256	93	471	404	332	5788
CSF	1070	444	135	67	290	132	55	2193
Nasopharynx	2841	934	646	223	173	25	6	4848
Other disease (non-invasive)	256	173	24	15	45	38	46	597
Missing	14	5	0	0	3	3	3	28
PCV period
Pre-PCV	3925	1439	671	250	418	230	177	7110
Post-PCV7	1355	547	153	52	211	143	113	2574
Post-PCV10	131	44	13	7	22	44	12	273
Post-PCV13	1592	671	210	86	314	177	131	3181
No universal introduction of PCV	176	89	14	3	17	8	9	316

Isolates were classified by PCV use in the country and year of their isolation. The pre-PCV period was defined as the years when no conjugate vaccine was used and the year of first PCV introduction, the post-PCV7 period from the second year of PCV7 introduction through to the first year of PCV10 introduction, the post-PCV10 period from the second year of PCV10 introduction through to the first year of PCV13 introduction and the post-PCV13 period from the second year of PCV13 introduction through to the last collection year. No universal introduction of PCV denotes years in which a nationwide immunisation policy did not exist.