Table 2.
Pneumococcal invasiveness for pairs of genotypes that significantly differed within a serotype.
| Serotype | Least invasive (predominant CC) | OR [95% CI] | Most invasive (predominant CC) | OR [95% CI] | Conservative OR fold change | Fisher's p-value (country) |
|---|---|---|---|---|---|---|
| 6A | GPSC5 (CC172) | 0.34 [0.12–1.01] | GPSC41 (CC1094) | 2.96 [1.61–5.45] | 1.6 | 0.0004 (ZA) |
| 14 | GPSC9 (CC63) | 0.62 [0.22–1.73] | GPSC18 (CC15) | 12.45 [2.82–54.98] | 1.6 | 0.0005 (ZA) |
| 16F | GPSC33 (CC4088) | 0.14 [0.06–0.36] | GPSC46 (CC30) | 2.62 [0.44–15.73] | 1.2 | 0.0099 (ZA) |
| 19F | GPSC21 (CC347) | 0.32 [0.19–0.54] | GPSC1 (CC320) | 1.49 [0.78–2.88] | 1.4 | 0.0006 (ZA) |
| 23B | GPSC7 (CC439) | 0.14 [0.05–0.42] | GPSC5 (CC172) | 3.81 [0.44–32.79] | 1.05 | 0.005 (USA) |
| 23F | GPSC14 ST6279 (CC6279) | 0.81 [0.43–1.54] | GPSC14 ST2059 (CC6279) | 5.31 [1.71–16.54] | 1.1 | 0.004 (ZA) |
GPSC (Global Pneumococcal Sequence Cluster) OR (Odds ratio), ST (Sequence Type), CC (Clonal Complex), ZA (South Africa), CI (confidence interval), The conservative fold change in OR was calculated by dividing the lower CI of the most invasive genotype by the upper CI of the least invasive genotype, within each serotype.