Table 5.
Microglial gene expression changes in the TASTPM mouse model.
| Gene | TASTPM | Age | Region | TASTPM:age | TASTPM:region | Age:region | TASTPM:age:region |
|---|---|---|---|---|---|---|---|
| Cd33 | 3.75E-23 | 1.43E-14 | 3.77E-36 | 5.62E-08 | 2.51E-05 | 0.003 | 6.62E-04 |
| Cd84 | 5.34E-31 | 4.23E-25 | 9.24E-16 | 3.55E-14 | 1.97E-10 | 5.22E-06 | 5.80E-07 |
| Fyb | 1.73E-18 | 6.02E-16 | 1.21E-10 | 6.24E-06 | 3.11E-04 | 1.93E-05 | 9.05E-06 |
| Fcer1g | 6.39E-34 | 1.04E-25 | 3.47E-49 | 7.08E-11 | 1.47E-06 | 0.106 | 3.35E-05 |
| Gpr34 | 2.26E-21 | 6.37E-18 | 3.42E-67 | 9.21E-09 | 1.43E-05 | 0.016 | 4.16E-05 |
| Adora3 | 3.52E-13 | 4.56E-18 | 3.95E-24 | 9.84E-11 | 6.22E-06 | 1.37E-05 | 1.89E-07 |
| Acy3 | 0.071 | 0.494 | 0.010 | 0.772 | 8.30E-04 | 0.027 | 0.019 |
| Alox5ap | 1.17E-15 | 5.69E-28 | 5.86E-32 | 6.58E-09 | 2.02E-04 | 0.153 | 5.10E-04 |
| Csf2ra | 0.608 | 0.013 | 1.31E-12 | 0.090 | 0.004 | 0.984 | 0.639 |
| C1qb | 1.29E-38 | 2.49E-29 | 6.95E-51 | 1.37E-10 | 1.87E-04 | 0.198 | 8.80E-06 |
| C3 | 3.24E-16 | 9.05E-34 | 6.32E-06 | 2.53E-10 | 0.290 | 0.003 | 3.31E-04 |
| Igsf6 | 0.260 | 0.510 | 0.845 | 0.712 | 0.910 | 0.160 | 0.969 |
| Ly86 | 2.91E-29 | 3.04E-26 | 8.80E-33 | 2.74E-10 | 2.27E-07 | 0.037 | 2.93E-06 |
| Laptm5 | 9.51E-21 | 9.32E-23 | 1.70E-60 | 8.07E-09 | 3.16E-05 | 0.417 | 2.19E-04 |
| P2ry13 | 2.00E-15 | 1.82E-18 | 2.30E-74 | 2.99E-05 | 0.005 | 0.177 | 0.001 |
| Spn | 0.137 | 0.518 | 0.648 | 0.593 | 0.723 | 0.746 | 0.698 |
| Sucnr1 | 0.186 | 0.011 | 0.481 | 0.003 | 0.044 | 0.026 | 0.044 |
| Tbxas1 | 8.07E-29 | 1.77E-15 | 2.19E-21 | 2.35E-09 | 4.10E-10 | 1.35E-04 | 1.23E-04 |
| Tlr7 | 6.24E-29 | 3.88E-17 | 8.02E-38 | 9.58E-12 | 2.89E-08 | 1.03E-04 | 1.22E-06 |
| Trem2 | 1.20E-35 | 1.73E-30 | 3.46E-42 | 5.36E-14 | 5.45E-7 | 3.54E-04 | 2.11E-08 |
Analysis of variance (ANOVA) results from the TASTPM mouse model of Alzheimer's disease are shown when transgenic mice and wild type mice were compared by age and brain region (e.g., cerebellum, hippocampus, or cortex). Significant findings (Bonferroni p-value threshold of 0.000357) are shown in bold. Data are courtesy of the Mouseac project (16).