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. 2019 Jun 4;10:1241. doi: 10.3389/fimmu.2019.01241

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Copyright © 2019 Ji, Wang, Yang, Wang, Huang, Xue and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Suppressing KLF4 deacetylation is necessary for FTY720-mediated the primary microglial M1-to-M2 polarization. (A) Knockdown LKB1 or HDAC1 reversed FTY720-induced the changes in the protein expressions of M1 markers (iNOS, green) and M2 markers (CD206, red) by Immunofluorescent staining. Scale bar = 20 μm. (B–G) Representative Western blots was used to quantify the expression of M1 markers (CD11b, COX-2, iNOS, and IL-1β) and M2 markers (CD206 and IGF-1a) in each group. Densitometric analysis of all Western blot bands was normalized to GAPDH. Statistical analysis was performed using One-way ANOVA followed by Bonferroni's post-hoc test and Two-way ANOVA. Data are presented as means ± SEMs, n = 4, *p < 0.05, **p < 0.01, compared with Con group, ^#p < 0.05, compared with OGD group. ^†p < 0.05, ^††p < 0.01, compared with OGD+FTY720 group.