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Parasiticidal concentrations of benznidazole (Bzl) exert anti-inflammatory effects through IL-10/STAT3/SOCS3 axis. When cardiomyocytes are stimulated with LPS and pre-treated with 15 μM of Bzl, IL-10 expression tends to increase. This induces the phosphorylation of STAT3 resulting in an increase in SOCS3 expression, thereby preventing NF-κB activation.
