Fig. 5.

Effect of acute inhibition of CXCR1/2 by reparixin on behavioral indices of chronic back pain in mice. The effects of a single injection of reparixin (30 mg/kg, i.p.) were evaluated 1, 3, 6 and 24 h after treatment. Reparixin had no effect on A) mechanical sensitivity measured with von Frey filaments, B) cold sensitivity measured with acetone-evoked behaviors or C) axial discomfort measured by grip strength in neither SPARC-null nor WT mice. Data is presented as mean ± SEM, n = 9–10 per SPARC-null groups, n = 4–6 per WT groups. Data was analyzed by two-way repeated measures ANOVA followed by Tukey's post hoc test.