Table 2.
Retina map: segmentation analysis (perifovea area)
| Retinal thickness | AD (N = 42) | MCI (N = 48) | NC (N = 45) |
P value |
|
|---|---|---|---|---|---|
| AD versus NC | MCI versus NC | ||||
| Inner average perifovea | 107.79(6.19) | 108.23(7.39) | 113.36(6.00) | <.001∗ | <.001∗ |
| Inner superior perifovea | 107.60(5.54) | 107.63(6.59) | 113.22(5.77) | <.001∗ | <.001∗ |
| Inner inferior perifovea | 104.21(7.47) | 105.65(7.96) | 108.91(6.80) | .004∗ | .036† |
| Inner nasal perifovea | 118.12(9.92) | 118.10(10.68) | 125.04(8.50) | .001∗ | .001∗ |
| Inner tempo perifovea | 101(5.81) | 101.83(8.17) | 106.27(6.07) | <.001∗ | .002∗ |
| Outer average perifovea | 167.21(6.78) | 171.79(8.72) | 173.24(8.78) | .001∗ | .394 |
| Outer superior perifovea | 170.10(8.06) | 173.79(9.31) | 175.87(8.80) | .003∗ | .256 |
| Outer inferior perifovea | 161.24(6.82) | 165.54(8.27) | 167.53(9.14) | <.001∗ | .242 |
| Outer nasal perifovea | 173.05(8.05) | 177(11.69) | 178.78(11.95) | .015† | .429 |
| Outer tempo perifovea | 164.55(7.59) | 170.48(9.23) | 171.73(9.39) | <.001∗ | .494 |
The retina contains ten layers: internal limiting membrane (ILM), nerve fiber layer (NFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), outer limiting membrane (OLM), photoreceptor, retinal pigment epithelium (RPE). The retina map divide the macular region retina into inner retina and outer retina, inner retina is from ILM to IPL and outer retina is from INL to RPE.
Data reported as mean and SD.
The bold values indicate the statistical significance.
Abbreviations: AD, Alzheimer's disease; MCI, mild cognitive impairment; NC, normal control; SD, standard deviation; Avg, average; superior, superior quadrant; inferior, inferior quadrant; nasal, nasal quadrant; tempo, temporal quadrant.
P < .01.
P < .05.