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. 2019 Jun 10;9:8401. doi: 10.1038/s41598-019-44835-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MAP3K3 affects NF-κB pathway activity and expression of EMT-related and cytoskeletal proteins. (A) Western blot analysis of the effect of MAP3K3 expression on the expression of key proteins of the NF-κB signalling pathway and EMT-related proteins in SKOV3 cells (Blank, sh-scramble, sh-MAP3K3-13, sh-MAP3K3-15), A2780 cells (Blank, sh-scramble, sh-MAP3K3-13 and sh-MAP3K3-15) and OV2008 (Blank, vector, MAP3K3 and MAP3K3 + QNZ). (B) Immunofluorescence assay to detect the effect of knockdown of MAP3K3 on EMT-related proteins in SKOV3 and A2780 cells. (C) Overexpression of MAP3K3 and/or blocking of NF-κB signalling pathway altered the expression levels of E-cadherin and N-cadherin in OV2008 cells.