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. 2019 Jun 10;9:8401. doi: 10.1038/s41598-019-44835-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between MAP3K3 and chemotherapeutic sensitivity. (A–C) MTT assay to detect the effect of knocking down MAP3K3 expression in SKOV3 cells or blocking the NF-κB pathway (SKOV3/QNZ) on the sensitivity to cisplatin (A), paclitaxel (B), and TNF-α (C). (D–F) MTT assay to detect the effect of overexpression of MAP3K3 and/or blocking of NF-κB pathway (MAP3K3/QNZ) on the sensitivity to cisplatin (D), paclitaxel (E), and TNF-α (F). (G,H) TUNEL assay to detect the cell apoptosis of four groups of cells induced by cisplatin in SKOV3 (G) and OV2008 (H) cells. Blue: nucleus; green: apoptotic cells. (I,J) Western blot to detect the effect of MAP3K3 on the NF-κB pathway and apoptosis-related proteins in SKOV3 (I, Blank, Scramble, sh-MAP3K3, Blank/QNZ) and OV2008 (J, Blank, Vector, MAP3K3 and MAP3K3/QNZ) cells. Repeated three independent experiments, ^*means p < 0.05, **means p < 0.01, ***means p < 0.001.