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. 2019 Jun 4;10:1279. doi: 10.3389/fimmu.2019.01279

Figure 4.

Figure 4

Cells were cultured with liposome-embedded MPLA (L-MPLA) alone or in combination with liposome-packed control siRNA (L-con siRNA) or L- αSOCS1siRNA for the indicated time points and analyzed for surface expression of CD80, CD86, and HLA-DR with specific antibodies (CD80-PE, CD86-PE, and HLA-DR-FITC) on a FACSCanto. Columns: mean of three different donors/experiments (n = 3) + standard deviation (std) as error bars. Statistics: Mann– Whitney U test, one-tailed, confidence intervals 95%, *p ≤ 0.05; ns, not significant. Line above the bars depicts the compared groups. Additionally performed test: Kruskal-Wallis. Number of groups: 12; HLA-DR: P-value 0.0056; sum value**; CD80: P-value 0.0027; sum value**; CD86: P-value 0.0009; sum value***. The medians of all three vary signif. (P < 0.05).