Table 1.

Summary of the generation of CNS insulin receptor knock-out models relating to the BBB.

Cell type	Model	Cre driver	References
Endothelial Cell	VENIRKO	Tie2	Vicent et al., 2003; Kondo et al., 2004
	EndoIRKO	Cdh5	Konishi et al., 2017; Rhea et al., 2018
Neuron	NIRKO	Nestin	Bruning et al., 2000; Schubert et al., 2004; Kleinridders et al., 2015
	nIR -/-	Synapsin	Freude et al., 2009; Stohr et al., 2013
Astrocyte	GIRKO	GFAP	Garcia-Caceres et al., 2016; Cai et al., 2018
Pericyte	PIR -/-	PDGFRβ2	Warmke et al., 2017

These references highlight the critical work investigating the role of the insulin receptor on BBB function in addition to memory impairments in CNS insulin resistance.