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Mixed evidence on low vitamin B12 levels and Alzheimer's disease risk in the literature
| Study | Sample | Method | Association evidence for low B12 and Alzheimer's |
|---|---|---|---|
| Clarke et al. 1998 [3] | 240 AD cases + 108 controls | Observational | Y |
| Moore et al. 2014 [4] | 1354 cognitive impairment | Observational | Y |
| Grarup et al. 2013 [5] | 45K Icelandic + Danish | B12 GWAS | N |
| Larsson et al. 2017 [6] | 17K AD cases + 37K controls | Mendelian Randomization | N |
Abbreviation: AD, Alzheimer's disease.
