Table 1.
Summary of Important microRNAs Involved in HCC Pathogenesis.
| MiRNA | Target Gene(s) | Mechanism | References |
|---|---|---|---|
| miR-20a↑ | EGFR/IL-6,MICB | Chemoresistance, Cytolysis | [38], [70], [75], [76] |
| miR-889↑ | MICB | Cytolysis | [70] |
| miR-106b, miR-93↑ | MCM7 | Cell cycle | [38], [77], [78] |
| miR-615-5p↑ | IGF-1, SHMT2 | NK cytolytic activity, proliferation, migration | [96], [145] |
| miR-30c-1↓ | TNF-α | Proliferation | [145] |
| miR-122↓ | CCL2 | Apoptosis, angiogenesis, metastasis | [87], [146] |
| miR-146a↓ | EGFR, ERK1/2, Stat5 |
Cell growth, apoptosis | [92], [93], [146] |
| miR-199a/b↓ | mTor,c-Met, PAK4 | Proliferation, metastasis, cell growth | [92], [93] |
| miR-214↓ | Ctnnb1 | Cell growth, invasion | [91, 92，95] |
| miR-486-5p↓ | IGF-1, ULBP2 | NK cytolytic activity | [95] |
Upregulation:↑ Downregulation: ↓.