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. 2019 Jun 4;13:551. doi: 10.3389/fnins.2019.00551

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Copyright © 2019 Kattuah, Rogelj, King, Shaw, Hortobágyi and Troakes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-localisation of TDP-43 and hnRNP E2. Double-labeling immunofluorescence shows inclusions positive for TDP-43 (red) (A1) and hnRNP E2 (green) (A2) in the frontal cortex of a subtype A case, the merged image (A3) shows numerous areas of co-localisation (case ID BBN_15298). Co-localisation is also seen in the hippocampus, panels (B1–B3) show a subtype A case (case ID 482 BBN_4568). Higher magnification images demonstrate the complete co-localisation of the TDP-43 and hnRNP E2 in a perinuclear inclusion from the subtype A case (C1–C3) and along a dystrophic neurite in a subtype C case (D1–D3) (case ID BBN_15303). Scale bar represents 100 μm in panels (A1–A3,B1–B3), 25 μm in panels (C1–C3,D1–D3).