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. 2019 Jun 4;13:551. doi: 10.3389/fnins.2019.00551

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Copyright © 2019 Kattuah, Rogelj, King, Shaw, Hortobágyi and Troakes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-localisation of ubiquitin and hnRNP E2. Double-labeling immunofluorescence of Ubiquitin (red) and hnRNP E2 (green) shows high levels of co-localisation within the frontal cortex (A1–A3) and hippocampus (B1–B3) of a subtype A case (case ID BBN_4568). Strong co-localisation can be seen within the inclusions in a subtype A case (C1–C3) (case ID BBN_15298). In a subtype C case, some inclusions show only ubiquitin positivity (D1) and some only hnRNP-E2 positivity (D2). Within inclusions showing both proteins, the co-localisation is not absolute (D3) (case ID BBN_15303). Scale bar represents 80 μm in panel (A1–A3), 50 μm in panel (B1–B3), 20 μm in panels (C1–C3,D1–D3).