Table 1.

Substrate binding residues in human LSD1, and orthologous residues in Arabidopsis LDL1 and LDL3.

Binding residues have been selected on the basis of the three-dimensional structure of human LSD1 (HsLSD1) in complex with a substrate-mimic peptide (PDB code 2V1D; Forneris et al., 2007). Orthologous residues in Arabidopsis LDL1 and LDL3 have been identified on the basis of structure-based sequence alignment using the molecular models of Arabidopsis LDL1 (Spedaletti et al., 2008) and LDL3 (present work). ^∗Conserved or conservatively substituted residues are shown in black, non-conserved residues in red.