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. 2019 Jun 4;13:123. doi: 10.3389/fnbeh.2019.00123

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Copyright © 2019 Lukić, Getselter, Koren and Elliott.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of acute tryptophan depletion (ATD) on depressive-like behavior in germ free (GF) and specific pathogen free (SPF) mice. Changes in immobility time in tail suspension test (A) and forced swim test (B) after ATD in GF and SPF mice. TRP⁺ - group receiving control amino acid mixture with tryptophan, TRP⁻ - group receiving amino acid mixture without tryptophan. *p < 0.05, **p < 0.01, LSD post hoc test, N = 11 mice per group.