Table 1B.
Representative top-30 genes commonly up-regulated (FC > 2) by IFNγ + LPS in VSMC, MΦ, and DC, reflecting SI between IFNγ and LPS in VSMC.
| No. | IFNγ + LPS induced common genes | VSMC | Binding site | ||||
|---|---|---|---|---|---|---|---|
| IFNγ | LPS | IFNγ + LPS | GAS | ISRE | NFκB | ||
| 1 | Cxcl9* | 82.2 | 4.0 | 2380.5 | • | – | • |
| 2 | F830016B08Rik* | 1272.1 | 6.4 | 2306.6 | • | • | • |
| 3 | Gm4841* | 1087.3 | 9.0 | 1650.3 | • | • | • |
| 4 | Nos2* | 1.8 | 90.9 | 933.3 | • | • | • |
| 5 | BC023105* | 600.8 | 19.9 | 909.4 | – | – | – |
| 6 | Gbp4* | 304.3 | 16.4 | 795.8 | • | • | • |
| 7 | Iigp1* | 687.7 | 9.2 | 779.3 | • | • | – |
| 8 | Ubd* | 95.6 | 5.8 | 655.1 | • | • | • |
| 9 | Gbp10* | 315.9 | 21.1 | 588.2 | • | • | • |
| 10 | Gbp9* | 304.8 | 22.9 | 586.1 | – | • | • |
| 11 | Gbp6* | 266.1 | 23.5 | 555.3 | • | • | • |
| 12 | Serpina3f* | 200.1 | 13.0 | 529.6 | • | • | • |
| 13 | Gbp11* | 302.3 | 13.6 | 482.7 | • | • | – |
| 14 | Gm12250 | 502.9 | 3.6 | 477.8 | • | • | – |
| 15 | Gbp8* | 215.5 | 12.9 | 405.2 | • | • | • |
| 16 | Ciita | 704.4 | 2.0 | 376.5 | • | • | • |
| 17 | Cxcl10* | 49.8 | 4.6 | 364.9 | • | • | • |
| 18 | Gbp1* | 295.0 | 17.5 | 364.8 | – | • | – |
| 19 | Gja4* | 82.3 | 1.6 | 329.9 | • | • | • |
| 20 | Gm4951* | 300.1 | 6.9 | 327.2 | • | – | – |
| 21 | Batf2* | 191.4 | 3.1 | 298.4 | • | • | – |
| 22 | Lcn2* | 3.8 | 36.5 | 289.2 | – | – | • |
| 23 | Gbp2* | 219.7 | 13.4 | 284.4 | – | • | • |
| 24 | Igtp | 328.8 | 5.3 | 274.1 | • | • | – |
| 25 | Tgtp2 | 261.9 | 2.6 | 262.5 | • | • | – |
| 26 | Gm5970* | 183.1 | 2.3 | 236.1 | – | – | – |
| 27 | Ccl8* | 115.8 | 18.6 | 231.4 | • | • | • |
| 28 | Tgtp1* | 216.7 | 2.4 | 222.4 | • | • | • |
| 29 | Gbp5* | 67.7 | 9.2 | 211.5 | • | • | • |
| 30 | Saa3* | 4.2 | 66.6 | 196.1 | • | – | • |
Gene expression levels were presented as FC relative to control in VSMCs. Signal Integrated genes (FC IFNγ + LPS > FC IFNγ + FC LPS) were marked by an asterisk (
*
). Overlapping genes between IFNγ + LPS- and IFNα + LPS-induced commonly up-regulated genes (Table 1A) were color-coded by blue. Presence of GAS, ISRE, or NFκB binding sites in the promoters of listed genes was indicated by a dot (•).